Utilizing this medicine with any of the following medicines isn't advised. Your health practitioner may well decide not to treat you with this particular medication or adjust a number of the other medicines you take.
There might be other side effects of promethazine/phenylephrine/codeine that are not stated below. Get hold of your Health care service provider if you think you will be possessing a aspect impact of a medicine.
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Glaucoma. Glaucoma is usually a affliction which could result in difficulty seeing or blindness as a result of damage to the optic nerve in the eye. Promethazine/phenylephrine/codeine could maximize pressure inside the eye and worsen slim-angle glaucoma.
Codeine is transformed to morphine in the human body. A lot of people transform codeine to morphine far more swiftly than others. These persons are named "extremely-speedy metabolizers of codeine". Make contact with your medical doctor immediately should you working experience Serious sleepiness, confusion, or shallow breathing.
Although the exact system of action of codeine is still unidentified, it is mostly thought to be mediated through the agonism of opioid receptors, specially the mu-opioid receptors.four Morphine was Formerly postulated to lead into the analgesic result of codeine due to O-demethylation of codeine to morphine by CYP2D6. Specially, CYP2D6 more info poor metabolizer didn't practical experience the analgesic result of codeine.two,ten Having said that, this is not likely to become the leading mechanism of motion of codeine as only 5% of codeine is metabolized to morphine.
on the codeine drug label cautioning versus prescribing codeine to kids of any age to deal with pain soon after surgical treatment to eliminate tonsils or adenoids. We also issued Drug Security Communications in July 2015 and September 2015 warning about the chance of serious respiratory difficulties in a few youngsters who metabolized codeine and tramadol considerably faster for their Energetic variety than regular (identified as ultra-fast metabolism), causing perhaps dangerously superior amounts within their bodies far too speedily.
Be sure to not overfill the measuring machine. This tends to assist protect against you from having excessive medication.
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Specified medicines shouldn't be utilised at or across the time of ingesting meals or feeding on selected forms of meals considering the fact that interactions may perhaps arise.
The a few fatalities happened outside the house the U.S. in kids young than six yrs. Elevated serum tramadol concentrations have been pointed out in all a few.
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Preserve promethazine/phenylephrine/codeine out in the attain of children. Promethazine/phenylephrine/codeine is a controlled compound since it can be misused or result in dependence.